Karl-Wilhelm Koch Selected Research

Guanylate Cyclase (Guanylyl Cyclase)

1/2019	A G86R mutation in the calcium-sensor protein GCAP1 alters regulation of retinal guanylyl cyclase and causes dominant cone-rod degeneration.
1/2018	Photoreceptor Guanylate Cyclase (GUCY2D) Mutations Cause Retinal Dystrophies by Severe Malfunction of Ca2+-Dependent Cyclic GMP Synthesis.
12/2015	Two retinal dystrophy-associated missense mutations in GUCA1A with distinct molecular properties result in a similar aberrant regulation of the retinal guanylate cyclase.
1/2014	Dysfunction of outer segment guanylate cyclase caused by retinal disease related mutations.
6/2010	Involvement of the calcium sensor GCAP1 in hereditary cone dystrophies.
3/2010	Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy.
8/2009	Mutations in the GUCA1A gene involved in hereditary cone dystrophies impair calcium-mediated regulation of guanylate cyclase.
1/2002	Retinal diseases linked with photoreceptor guanylate cyclase.

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Karl-Wilhelm Koch Research Topics

Disease

5	Retinal Degeneration 01/2019 - 01/2014
5	Cone-Rod Dystrophies 01/2019 - 01/2002
5	Cone Dystrophy 08/2017 - 08/2009
4	Retinal Dystrophies 01/2021 - 12/2015
3	Retinal Diseases 01/2018 - 01/2002
2	Retinitis Pigmentosa (Pigmentary Retinopathy) 03/2022 - 01/2020
2	Leber Congenital Amaurosis 01/2018 - 01/2018
2	Macular Degeneration (Age-Related Maculopathy) 01/2017 - 12/2015
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2016
1	Acquired Immunodeficiency Syndrome (AIDS) 07/2013
1	Ganglion Cysts (Ganglion) 04/2012
1	Blindness (Hysterical Blindness) 01/2002

Drug/Important Bio-Agent (IBA)

8	Guanylate Cyclase (Guanylyl Cyclase)IBA 01/2019 - 01/2002
7	Proteins (Proteins, Gene)FDA Link 03/2022 - 12/2015
7	CalciumIBA 01/2020 - 08/2009
5	Guanylate Cyclase-Activating ProteinsIBA 03/2022 - 10/2014
2	Retinaldehyde (Retinal)IBA 01/2019 - 12/2015
2	Cyclic GMPIBA 01/2018 - 12/2015
2	EnzymesIBA 12/2015 - 07/2013
2	guanylate cyclase 1IBA 01/2014 - 07/2013
1	Aspartic Acid (Aspartate)FDA Link 03/2022
1	Histidine (L-Histidine)FDA Link 03/2022
1	NucleotidesIBA 01/2018
1	Amino Acids FDA Link 01/2016
1	AntibodiesIBA 04/2012